Citation
Ahmad, Syahida and Ahmad Israf, Daud and Lajis, Nordin and Shaari, Khozirah and Mohamad, Habsah and Karim, Jasril and Permana, Dharma and I., Norhadiani
(2006)
Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages.
Pharmaceutical Biology, 44 (1).
pp. 50-59.
ISSN 1388-0209; ESSN: 1744-5116
Abstract
The current study was designed to evaluate whether compounds isolated from local medicinal plants in Malaysia suppressed nitric oxide (NO) production in inflammation. The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-γ. (IFN-γ.) and lipopolysaccharide (LPS). Our current study has identified four phytochemicals, namely atrovirinone, cardamonin, flavokawin B, and zerumbone, that inhibit pathological NO generation. These compounds are candidates for further bioassay studies to determine their suitability as drug leads.
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Official URL or Download Paper: http://www.tandfonline.com/doi/abs/10.1080/1388020...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Faculty of Science Institute of Bioscience |
| DOI Number: | https://doi.org/10.1080/13880200500530765 |
| Publisher: | Taylor & Francis |
| Keywords: | Macrophages; Nitric oxide; Phytochemicals |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 18 Sep 2015 03:23 |
| Last Modified: | 18 Sep 2015 03:23 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/13880200500530765 |
| URI: | http://psasir.upm.edu.my/id/eprint/40439 |
| Statistic Details: | View Download Statistic |
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