Citation
Abstract
Five flavonoids, including 3,7,4′-trimethoxy-5-hydroxyflavone (1), 3,4′-dimethoxy-5,7-dihydroxyflavone (2), 5,7,4′-trimethoxy-3-hydroxyflavone (3), 3,5,7,4′-tetramethoxyflavone (4), and 7,4′-dimethoxy-3,5-dihydroxyflavone (5), were isolated from the rhizome of Hedychium thyrsiforme and assayed for antioxidant and antitumor promoting activities. The antioxidant assays showed that 5,7,4′-trimethoxy-3-hydroxyflavone, 7,4′-dimethoxy-3,5-dihydroxyflavone and 3,4′-dimethoxy-5,7-dihydroxyflavone had strong activities. Only two compounds, 5,7,4′-trimethoxy-3-hychoxyflavone and 7,4′-dimethoxy-3,5-dihydroxyflavone, were found to be strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavengers with fifty percent inhibition concentration (IC50) values of 92 and 119 μM, respectively. Antitumor promoting assays indicated that all the flavonoids showed strong inhibition activity towards Epstein-Barr virus (EBV) activation in Raji cells.
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Official URL or Download Paper: http://www.tandfonline.com/doi/abs/10.1080/1388020...
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Additional Metadata
Item Type: | Article |
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Divisions: | Institute of Bioscience Universiti Putra Malaysia |
DOI Number: | https://doi.org/10.1080/13880200308951344 |
Publisher: | Taylor & Francis |
Keywords: | Hedychium thyrsiforme Smith; Antioxidant activity; Antitumor promoting activity; Flavonoids |
Depositing User: | Nabilah Mustapa |
Date Deposited: | 18 Sep 2015 03:15 |
Last Modified: | 06 Aug 2024 03:12 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/13880200308951344 |
URI: | http://psasir.upm.edu.my/id/eprint/40438 |
Statistic Details: | View Download Statistic |
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