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Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme


Citation

Karim, Jasril and Lim, Yang Mooi and Lajis, Nordin and Ali, Abdul Manaf and Sukari, Mohd Aspollah and Rahman, A. A. and Othman, A. G. and Kikuzaki, Hiroe and Nakatani, Nobuji (2003) Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme. Pharmaceutical Biology, 41 (7). pp. 506-511. ISSN 1388-0209; ESSN: 1744-5116

Abstract

Five flavonoids, including 3,7,4′-trimethoxy-5-hydroxyflavone (1), 3,4′-dimethoxy-5,7-dihydroxyflavone (2), 5,7,4′-trimethoxy-3-hydroxyflavone (3), 3,5,7,4′-tetramethoxyflavone (4), and 7,4′-dimethoxy-3,5-dihydroxyflavone (5), were isolated from the rhizome of Hedychium thyrsiforme and assayed for antioxidant and antitumor promoting activities. The antioxidant assays showed that 5,7,4′-trimethoxy-3-hydroxyflavone, 7,4′-dimethoxy-3,5-dihydroxyflavone and 3,4′-dimethoxy-5,7-dihydroxyflavone had strong activities. Only two compounds, 5,7,4′-trimethoxy-3-hychoxyflavone and 7,4′-dimethoxy-3,5-dihydroxyflavone, were found to be strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavengers with fifty percent inhibition concentration (IC50) values of 92 and 119 μM, respectively. Antitumor promoting assays indicated that all the flavonoids showed strong inhibition activity towards Epstein-Barr virus (EBV) activation in Raji cells.


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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
Universiti Putra Malaysia
DOI Number: https://doi.org/10.1080/13880200308951344
Publisher: Taylor & Francis
Keywords: Hedychium thyrsiforme Smith; Antioxidant activity; Antitumor promoting activity; Flavonoids
Depositing User: Nabilah Mustapa
Date Deposited: 18 Sep 2015 03:15
Last Modified: 06 Aug 2024 03:12
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/13880200308951344
URI: http://psasir.upm.edu.my/id/eprint/40438
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