Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica

2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda elliptica , were assayed for anti-HIV, cytotoxic and antimicrobial activites. Only damnacanthal showed moderate activity against HIV. It was cytotoxic towards the MCF-7 (breast carcinoma) and CEM-SS (T-lymphoblastic leukaemia) cell line. Nordamnacanthal was very cytotoxic against the CEM-SS cell lines. Other anthraquinones that showed strong cytotoxicity towards the cell lines tested were lucidin-?-methyl ether (CEM-SS and MCF-7) and rubiadin (CEM-SS). Three anthraquinones viz., nordamnacanthal, damnacanthal and morindone, were found to have strong antimicrobial activity.

Preview Text (Abstract) Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica.pdf - Published Version Download (36kB) | Preview Text Antiviral Cyototoxic And Antimicrobial Activities Of Anthraquinones Isolated From The Roots Of Morinda Elliptica.pdf - Published Version Download (211kB) Official URL or Download Paper: http://www.tandfonline.com/doi/abs/10.1076/1388-02...

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