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Neuroprotective potential of secondary metabolites from Melicope lunu-ankenda (Rutaceae)


Citation

Mohamed, Zeinab Abdulwanis and Eliaser, Enas Mohamed and Mazzon, Emanuela and Rollin, Patrick and Ee, Gwendoline Cheng Lian and Abdull Razis, Ahmad Faizal (2019) Neuroprotective potential of secondary metabolites from Melicope lunu-ankenda (Rutaceae). Molecules, 24 (17). art. no. 3109. pp. 1-21. ISSN 1420-3049

Abstract

Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the M. lunu-ankenda plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of M. lunu-ankenda major secondary metabolites in neurodegenerative diseases.


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Official URL or Download Paper: https://www.mdpi.com/1420-3049/24/17/3109

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Science
Institute of Bioscience
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.3390/molecules24173109
Publisher: MDPI
Keywords: Polyphenols; Coumarins; Alkaloids; Melicope lunu-ankenda; Neuroprotection; Neurodegenerative diseases
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:11
Last Modified: 04 May 2020 16:11
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules24173109
URI: http://psasir.upm.edu.my/id/eprint/38283
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