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In vitro anti-viral activity of Centella asiatica L., Curcuma longa L. and Strobilanthes crispus L. against herpes virus


Citation

H., Hanisa and Mohd Lila, Mohd Azmi and Mohamed, Suhaila and Somchit, Muhammad Nazrul (2014) In vitro anti-viral activity of Centella asiatica L., Curcuma longa L. and Strobilanthes crispus L. against herpes virus. International Journal of Pharma and Bio Sciences, 5 (1B). pp. 42-52. ISSN 0975-6299

Abstract / Synopsis

Extracts of three different plant species; Curcuma longa L., Centella asiatica L. and Strobilanthes crispus L. which are used widely in Malaysian traditional medicine are investigated for antiviral activity against alpha-herpesvirus (pseudorabies virus). The methanol extract (ME) and aqueous extract (AE) were tested in three cell lines; African Green Monkey Kidney (Vero), Baby Hamster Kidney (BHK) and Rabbit Kidney (RK) cells, at non-cytotoxic concentrations. Assays were developed to determine the characteristics of anti pseudorabies virus (PrV) activities, as anti-viral attachment, anti-prophylactic and /or virucidal. All plant extracts showed marked virucidal ability and considerable prophylactic and anti-viral attachment activities. Plant ME always showed better antiviral activities than plant AE. Curcuma longa L. showed a better virucidal and prophylactic effect (with more than 70% cell viability at 25 μg/ml) for ME and AE. While Centella asiatica L. and Strobilanthes crispus L. were most active as anti-viral attachment agent with percent cell viability up to 60%. It was also found that the anti-viral activities were varies in different cell lines tested. Therefore, the extracts of all three plant species exhibited anti PrV and they could be further investigated for medical purposes.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Biotechnology
Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Halal Products Research Institute
Institute of Bioscience
Keywords: Centella asiatica L.; Curcuma longa L.; Strobilanthes crispus L.; In vitro anti-herpesvirus
Depositing User: Nabilah Mustapa
Date Deposited: 18 Dec 2015 15:52
Last Modified: 18 Dec 2015 15:52
URI: http://psasir.upm.edu.my/id/eprint/38004
Statistic Details: View Download Statistic

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