Citation
Abstract
Extracts of three different plant species; Curcuma longa L., Centella asiatica L. and Strobilanthes crispus L. which are used widely in Malaysian traditional medicine are investigated for antiviral activity against alpha-herpesvirus (pseudorabies virus). The methanol extract (ME) and aqueous extract (AE) were tested in three cell lines; African Green Monkey Kidney (Vero), Baby Hamster Kidney (BHK) and Rabbit Kidney (RK) cells, at non-cytotoxic concentrations. Assays were developed to determine the characteristics of anti pseudorabies virus (PrV) activities, as anti-viral attachment, anti-prophylactic and /or virucidal. All plant extracts showed marked virucidal ability and considerable prophylactic and anti-viral attachment activities. Plant ME always showed better antiviral activities than plant AE. Curcuma longa L. showed a better virucidal and prophylactic effect (with more than 70% cell viability at 25 μg/ml) for ME and AE. While Centella asiatica L. and Strobilanthes crispus L. were most active as anti-viral attachment agent with percent cell viability up to 60%. It was also found that the anti-viral activities were varies in different cell lines tested. Therefore, the extracts of all three plant species exhibited anti PrV and they could be further investigated for medical purposes.
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Official URL or Download Paper: http://www.ijpbs.net/archive-issue.php?issueid=25
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Food Science and Biotechnology Faculty of Medicine and Health Science Faculty of Veterinary Medicine Halal Products Research Institute Institute of Bioscience |
| Keywords: | Centella asiatica L.; Curcuma longa L.; Strobilanthes crispus L.; In vitro anti-herpesvirus |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 18 Dec 2015 07:52 |
| Last Modified: | 18 Dec 2015 07:52 |
| URI: | http://psasir.upm.edu.my/id/eprint/38004 |
| Statistic Details: | View Download Statistic |
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