UPM Institutional Repository

Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells


Citation

Cletus, Ude Chinedu and Sulaiman, Shamsul and Ng, Min Hwei and Chen, Cheng Hui and Htwe, Ohnmar and Amaramalar, Naicker Sylva and Hassan, Shariful and Djorjevic, Ivan and Mohammad Yahya, Norhamdan and Saim, Aminuddin and Idrus, Ruszymah (2014) Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells. Regenerative Research, 3 (2). pp. 50-52. ISSN 2232-0822

Abstract

The aim of this study was to quantify the functional improvements of osteoarthritic (OA) knee joints after treatment with chondrogenically induced pluripotent stem cells. OA was induced in the right knee joints by the resection of the anterior cruciate ligament and medial meniscus. Nine sheep were divided equally into 3 groups. Two treatment groups received either autologous chondrogenically induced adipose-derived stem cells (ADSCs) or bone marrow stem cells (BMSCs), while the control group received basal medium. Electromyography evaluations (EMGs) were conducted at week 0 (pre-OA), 8 (post-OA) and 24 (post-treatment), and compared to ascertain recovery in joint function. Multifocal subchondral lesions were developed after OA inductions and the treatment groups demonstrated the presence of regenerated neocartilages, evidenced by the presence of PKH26 tracking dye. Post-treatment EMGs showed that the controls retained significant reductions in amplitude compared to the pre-OA values, whereas ADSCs and BMSCs samples had no further significant reductions in amplitude post treatments (p<0.05). ADSCs and BMSCs treated knee joints had structural regeneration of cartilage; confirmed by PKH26 dye. The EMG analysis provided evidence of functional recovery associated to the structural regenerations.


Download File

[img]
Preview
PDF (Abstract)
Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells.pdf

Download (36kB) | Preview
Official URL or Download Paper: http://regres.tesma.org.my/past-issues.html

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Publisher: Tissue Engineering and Regenerative Medicine Society of Malaysia
Keywords: Cell therapy; Cartilage regeneration; Mesenchymal stem cells; EMG
Depositing User: Nabilah Mustapa
Date Deposited: 01 Feb 2016 02:31
Last Modified: 01 Feb 2016 02:31
URI: http://psasir.upm.edu.my/id/eprint/37975
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item