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GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity


Javadi, Neda and Abas, Faridah and Abdul Hamid, Azizah and Simoh, Sanimah and Shaari, Khozirah and Ismail, Intan Safinar and Mediani, Ahmed and Khatib, Alfi (2014) GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity. Journal of Food Science, 79 (6). C1130-C1136. ISSN 0022-1147; ESSN: 1750-3841


Cosmos caudatus, which is known as “Ulam Raja,” is an herbal plant used in Malaysia to enhance vitality. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol (EtOH) were employed. Gas chromatography-mass spectrometry (GC-MS) and orthogonal partial least-squares (OPLS) analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained OPLS scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different ethanol concentrations. GC-MS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. In addition, catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified and indicate the potential α-glucosidase inhibitory activity of this herb.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Institute of Bioscience
DOI Number: https://doi.org/10.1111/1750-3841.12491
Publisher: Institute of Food Technologists
Keywords: Cosmos caudatus; GC-MS; Diabetes; Metabolomics; α-glucosidase inhibitory activity
Depositing User: Nabilah Mustapa
Date Deposited: 22 Apr 2016 04:01
Last Modified: 22 Apr 2016 04:01
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1111/1750-3841.12491
URI: http://psasir.upm.edu.my/id/eprint/37740
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