Citation
Abstract
Cosmos caudatus, which is known as “Ulam Raja,” is an herbal plant used in Malaysia to enhance vitality. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol (EtOH) were employed. Gas chromatography-mass spectrometry (GC-MS) and orthogonal partial least-squares (OPLS) analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained OPLS scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different ethanol concentrations. GC-MS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. In addition, catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified and indicate the potential α-glucosidase inhibitory activity of this herb.
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Official URL or Download Paper: http://onlinelibrary.wiley.com/doi/10.1111/1750-38...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Food Science and Technology Institute of Bioscience |
| DOI Number: | https://doi.org/10.1111/1750-3841.12491 |
| Publisher: | Institute of Food Technologists |
| Keywords: | Cosmos caudatus; GC-MS; Diabetes; Metabolomics; α-glucosidase inhibitory activity |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 22 Apr 2016 04:01 |
| Last Modified: | 22 Apr 2016 04:01 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1111/1750-3841.12491 |
| URI: | http://psasir.upm.edu.my/id/eprint/37740 |
| Statistic Details: | View Download Statistic |
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