Citation
Abstract
Children are the vulnerable group in the agricultural community due to their early exposure to pesticides through the dynamic interplay between genetic predisposition, environment, and host-related factors. This study aims to identify the possible association between the depression in blood cholinesterase level and genotoxic effect among farm children. The results of micronuclei assay and comet assay showed that the reduced blood cholinesterase level from organophosphate pesticide exposure is significantly associated with an increase in chromosome breakage and DNA strand breaks. These genotoxicity end points suggest that farm children's cells experience early DNA damage that may lead to uncontrolled cell proliferation during their adulthood. Thus, farm children who grow up near pesticide-treated farmland have a higher probability of developing cancer than children with minimal or zero exposure to pesticides.
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Official URL or Download Paper: http://www.tandfonline.com/doi/abs/10.1080/1059924...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Agriculture Faculty of Medicine and Health Science |
| DOI Number: | https://doi.org/10.1080/1059924X.2013.866917 |
| Publisher: | Taylor & Francis |
| Keywords: | Children; Cholinesterase depression; Genotoxicity risk; Organophosphate |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 22 Apr 2016 03:29 |
| Last Modified: | 22 Apr 2016 03:29 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/1059924X.2013.866917 |
| URI: | http://psasir.upm.edu.my/id/eprint/37566 |
| Statistic Details: | View Download Statistic |
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