Determination of urocanic acid, a compound implicated in histamine toxicity, and assessment of biogenic amines relative to urocanic acid content in selected fish and fish products

The contents of trans- and cis-urocanic acid (cis-UCA), NaCl and moisture, and pH of sixty-seven fish and shrimp products, including salted anchovy, different types of salted fish, salted shrimp and shrimp paste collected in Malaysia, were examined. Included in the analysis was determination of the contents of nine biogenic amines. The average levels of trans- and cis-UCA in salted anchovy, salted fish, salted shrimp and shrimp paste were 9.67 and 7.25, 14.2 and 11.0, 36.6 and 22.5, 6.96 and 18.7 mg/kg, respectively. In general, the average levels of trans- and cis-UCA were much lower than the histamine levels in fish products. Results showed no strong correlation of pH, salt and moisture contents with trans- and cis-UCA, nor with histamine. Biogenic amines were also detected in processed fish and shrimp products where the most abundant biogenic amine was putrescine with an average level of 227 mg/kg in shrimp paste. Thus, the high rates of cancers in consumers who consume dried salted fish could be indicative of the synergistic effects of biogenic amines and cis-UCA.

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