Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng

Citation

Ahmad, Kartini and Tan, Siow Ping and Md. Sukari, Mohd. Aspollah and Ali, Abdul Manaf and Nafiah, Mohd Azlan (2014) Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng. American Journal of Plant Sciences, 5 (19). pp. 2869-2877. ISSN 2158-2742; ESSN: 2158-2750

Abstract

Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.4236/ajps.2014.519302
Publisher:	Scientific Research Publishing
Keywords:	Carbazole; Rutaceae; Murraya koenigii; NMR; Cytotoxic
Depositing User:	Nabilah Mustapa
Date Deposited:	25 Jul 2015 03:43
Last Modified:	21 Aug 2015 04:08
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4236/ajps.2014.519302
URI:	http://psasir.upm.edu.my/id/eprint/36953
Statistic Details:	View Download Statistic

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