Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts

Citation

Subramani, Tamilselvan and Rao, Suresh and Senthilkumar, Kamatchiammal and Perisamy, Saundararajan and Mohamed Alitheen, Noorjahan Banu (2014) Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts. Biocell, 37 (3). pp. 71-76. ISSN 0327-9545; ESSN: 1667-5746

Abstract

The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibro- blast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells.

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Official URL or Download Paper: http://www.cricyt.edu.ar/biocell/vol/37_3.html

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Biotechnology and Biomolecular Sciences
Publisher:	Centro Regional de Investigaciones Cientificas y Tecnologicas
Keywords:	Angiotensin; c-Jun; c-Fos; Transcription factor; Cyclosporine; Gingival overgrowth
Depositing User:	Nabilah Mustapa
Date Deposited:	24 Jun 2015 03:11
Last Modified:	26 Jan 2016 07:38
URI:	http://psasir.upm.edu.my/id/eprint/36461
Statistic Details:	View Download Statistic

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