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Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments


Citation

Kao, Ta Chun and Lee, Henry Hsin Chung and Higuchi, Akon and Ling, Qing Dong and Yu, Wan Chun and Chou, Yu Hsuan and Wang, Pin Yu and Kumar, S. Suresh and Chang, Yu and Chen, Yung Hung and Chang, Yung and Chen, Da Chung and Hsu, Shih Tien (2014) Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments. Journal of Biomedical Materials Research Part B: Applied Biomaterial, 102 (3). pp. 463-476. ISSN 1552-4973; ESSN: 1552-4981

Abstract

Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes. CSCs persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumorigenic clones. The purification or depletion (suppression) of CSCs should be useful for analyzing CSC characteristics and for clinical application. CSCs can be selectively suppressed from colon cancer cells containing adipose-derived stem cells (ADSCs) on Pluronic-grafted dishes, while ADSCs remain on the dishes. ADSCs on Pluronic-grafted dishes after the suppression of the CSCs can differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, and neuronal cells. The CSCs and ADSCs exhibited different characteristics. The selection of ADSCs was possible on Pluronic-grafted dishes that suppressed the CSCs from the fat tissues of cancer patients (i.e., cell-sorting dishes), which was explained by specific biomedical characteristics of Pluronic. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 463–476, 2014.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1002/jbm.b.33024
Publisher: Wiley
Keywords: Pluronic; Cell-sorting dish; Nanosegment; Extracellular matrix; Stem cell
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 14 Jan 2016 03:42
Last Modified: 14 Jan 2016 03:42
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/jbm.b.33024
URI: http://psasir.upm.edu.my/id/eprint/35537
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