Citation
Bayat, Saadi and Tejo, Bimo Ario and Abd. Malek, Emilia and Salleh, Abu Bakar and Mohd Yahaya, Normi and Abdul Rahman, Mohd Basyaruddin
(2014)
Rational design of mimetic peptides based on aldo-ketoreductase enzyme as asymmetric organocatalysts in aldol reactions.
RSC Advances, 4 (73).
pp. 38859-38868.
ISSN 2046-2069
Abstract
Peptides as a kind of important chiral scaffold are broadly identified for their obvious advantages, diverse structures and accessibility. Based on promiscuous aldo-keto-reductase enzymes, several mimetic peptides were designed which were synthesized and tested as multifunctional organocatalysts in direct asymmetric aldol reactions. The corresponding aldol products were produced with high yields (up to 97%) and excellent diastereoselectivities (up to 99/1) and enantioselectivities (>98%) under mild reaction selectivity and enantioselectivity. The secondary structures of peptide catalysts provide an understanding of their mechanism.
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Official URL or Download Paper: http://pubs.rsc.org/en/content/articlelanding/2014...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Faculty of Science |
| DOI Number: | https://doi.org/10.1039/c4ra04866k |
| Publisher: | Royal Society of Chemistry |
| Keywords: | Rational design; Mimetic peptides; Aldo-ketoreductase enzyme; Asymmetric organocatalysts; Aldol reactions |
| Depositing User: | Nurul Ainie Mokhtar |
| Date Deposited: | 31 Dec 2015 01:24 |
| Last Modified: | 05 Apr 2017 05:03 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1039/c4ra04866k |
| URI: | http://psasir.upm.edu.my/id/eprint/35158 |
| Statistic Details: | View Download Statistic |
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