Citation
Tan Wen Siang
(2014)
Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components.
PI2014702540.
Abstract
The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding region. The present invention further provides spherical epitope-displaying virus-like particles (VLPs) comprising the MrNV capsid protein and one or more immunogenic components, such as ‘a’ determinant of HBV and M2e of influenza virus. The particles may contain one or more copies of each epitope. The invention further provides a method of producing such VLPs, and uses of such VLPs.
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Additional Metadata
| Item Type: | Patent |
|---|---|
| Application Number: | PI2014702540 |
| Filing Date: | 2014-09-09 |
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences |
| Keywords: | Recombinant plasmid; Immunogenic component |
| Depositing User: | Mohd Hafiz Che Mahasan |
| Date Deposited: | 24 Apr 2015 13:38 |
| Last Modified: | 24 Apr 2015 13:38 |
| URI: | http://psasir.upm.edu.my/id/eprint/33963 |
| Statistic Details: | View Download Statistic |
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