Citation
Abstract
Insulin gene therapy is one of many envisioned alternative treatments of diabetes. Diabetes gene therapy would be possible if insulin could be produced in a regulated and specifically in a sensitive manner dependent on the blood glucose level.Therefore, the present invention relates to a method for the isolation of GLP-1 expressing cells, to nucleic acids sequence construction or vectors useful for isolating GLP-1 expressing cell and to the GLP-1 expressing cells isolated therewith. Furthermore, the inventions relates to a method of nucleic acids sequence construction or vectors under the control of the GLP-1 promoter expressing insulin in a recombinant GLP-1 expressing cell line. The cells of the present invention are particular useful for the treatment of diabetes and may be used in a gene therapy approach to treat diabetes and other disorders related to the nutrient metabloism.
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Additional Metadata
Item Type: | Patent |
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Divisions: | Faculty of Medicine and Health Science |
Keywords: | GLP-1; Insulin; Diabetes. |
Depositing User: | Junaini Mohd Yusof |
Date Deposited: | 07 Oct 2014 01:48 |
Last Modified: | 11 Dec 2019 09:45 |
URI: | http://psasir.upm.edu.my/id/eprint/32198 |
Statistic Details: | View Download Statistic |
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