Citation
Yap, Wei Boon and Tey, Beng Ti and Mohammed Alitheen, Noorjahan Banu and Tan, Wen Siang
(2012)
Enhanced antigenicity of Nipah virus nucleocapsid protein displayed on hepatitis B core antigen.
In: International Conference on One Health and 24th VAM Congress 2012, 21-23 Sept. 2012, Marriott Putrajaya. (pp. 324-326).
Abstract
Display of the nucleocapsid protein (NP) of Nipah virus (NiV) on the hepatitis B core (HBc) particle enhances the antigenicity of the NP. In addition, the NP fused to the amino-teminus (NP401-532 HBc) and immunodominant loop of HBc (HBc79.80NP4O1'S31) was shown to be less sensitive to proteinase K. Some of the proteinase K treated NP401.32HBc and HBc79.80NP,O].s32 remained intact and antigenic. These results indicated two important implications, (1) the use of HBc virus -like particle as a carrier platform for foreign epitopes, (2 ) the use of NP401.532HBc as a diagnostic reagent for NiV infection.
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Additional Metadata
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Institute of Bioscience |
| Notes: | Full text are available at Special Collection Division Office. |
| Keywords: | Nipah virus; Fusion protein; Nucleocapsid; Hepatitis B core antigen; Virus-like particles |
| Depositing User: | Samsida Samsudin |
| Date Deposited: | 03 Sep 2014 01:29 |
| Last Modified: | 09 Jan 2017 09:33 |
| URI: | http://psasir.upm.edu.my/id/eprint/31947 |
| Statistic Details: | View Download Statistic |
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