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Steroids from Dysoxylum grande (Meliaceae) leaves


Low, Kok Wah and Abas, Faridah and Cordell, Geoffrey A. and Ito, Hideyuki and Ismail, Intan Safinar (2013) Steroids from Dysoxylum grande (Meliaceae) leaves. Steroids, 78 (2). pp. 210-219. ISSN 0039-128X; ESSN: 1878-5867


Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation of spectroscopic data, and their relative configurations were established by NOESY 2D NMR data. All of the isolates were tested for anti-acetylcholinesterase activity using thin layer chromatography (TLC)-bioautography with fast blue B salt. Only grandol A (1) and B (2) showed positive results, with clear discoloration at a concentration of 12.5 ppm. However, the obtained IC50 values for grandol A and B, when using Ellman’s method, were not significant (>200 μg/ml).

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Faculty of Food Science and Technology
Institute of Bioscience
DOI Number: https://doi.org/10.1016/j.steroids.2012.09.011
Publisher: Elsevier
Keywords: Dysoxylum grande; Grandol derivatives; Secodammarenoic acid derivative; Anti-acetylcholinesterase.
Depositing User: Umikalthom Abdullah
Date Deposited: 11 Sep 2014 03:53
Last Modified: 01 Oct 2015 07:30
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.steroids.2012.09.011
URI: http://psasir.upm.edu.my/id/eprint/30301
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