Citation
Abstract
Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation of spectroscopic data, and their relative configurations were established by NOESY 2D NMR data. All of the isolates were tested for anti-acetylcholinesterase activity using thin layer chromatography (TLC)-bioautography with fast blue B salt. Only grandol A (1) and B (2) showed positive results, with clear discoloration at a concentration of 12.5 ppm. However, the obtained IC50 values for grandol A and B, when using Ellman’s method, were not significant (>200 μg/ml).
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science Faculty of Food Science and Technology Institute of Bioscience |
| DOI Number: | https://doi.org/10.1016/j.steroids.2012.09.011 |
| Publisher: | Elsevier |
| Keywords: | Dysoxylum grande; Grandol derivatives; Secodammarenoic acid derivative; Anti-acetylcholinesterase. |
| Depositing User: | Umikalthom Abdullah |
| Date Deposited: | 11 Sep 2014 03:53 |
| Last Modified: | 01 Oct 2015 07:30 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.steroids.2012.09.011 |
| URI: | http://psasir.upm.edu.my/id/eprint/30301 |
| Statistic Details: | View Download Statistic |
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