Citation
Mustahil, Noorul Adawiyah and Sukari, Mohd Aspollah and Abdul, Ahmad Bustamam and Ali, Nor Azah and Ee, Gwendoline Cheng Lian
(2013)
Evaluation of biological activities of Alpinia mutica Roxb.
and its chemical constituents.
Pakistan Journal of Pharmaceutical Sciences, 26 (2).
pp. 391-395.
ISSN 1011-601X
Abstract
Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 µg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 µg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science Institute of Bioscience |
| Publisher: | University of Karachi. Faculty of Pharmacy |
| Keywords: | Alpinia mutica; CEMss; Flavokawin; Antimicrobial; DPPH |
| Depositing User: | Umikalthom Abdullah |
| Date Deposited: | 18 Jun 2014 08:04 |
| Last Modified: | 08 Oct 2015 01:28 |
| URI: | http://psasir.upm.edu.my/id/eprint/30037 |
| Statistic Details: | View Download Statistic |
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