Citation
Abstract
The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
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Official URL or Download Paper: http://www.mdpi.com/1420-3049/18/2
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science Faculty of Medicine and Health Science |
| DOI Number: | https://doi.org/10.3390/molecules18021985 |
| Publisher: | MDPI |
| Keywords: | Cytotoxicity; Mesua beccariana; Mesua congestiflora; Mesua ferrea; Structure-activity relationship; Xanthones. |
| Depositing User: | Umikalthom Abdullah |
| Date Deposited: | 30 May 2014 07:00 |
| Last Modified: | 29 Dec 2015 03:54 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules18021985 |
| URI: | http://psasir.upm.edu.my/id/eprint/30008 |
| Statistic Details: | View Download Statistic |
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