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Xanthones from Calophyllum gracilipes and their cytotoxic activity.


Mad Nasir, Nadiah and Rahmani, Mawardi and Shaari, Khozirah and Kassim, Nur Kartinee and Go, Rusea and Stanslas, Johnson and Jeyaraj, Ethel Jeyaseela (2013) Xanthones from Calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana, 42 (9). pp. 1261-1266. ISSN 0026-6039


Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00μM.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Universiti Kebangsaan Malaysia
Keywords: Calophyllum gracilipes; Gracixanthone; Sterols; Trapezifolixanthone; Zeyloxanthanone
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 08 Dec 2014 02:04
Last Modified: 07 Oct 2015 06:24
URI: http://psasir.upm.edu.my/id/eprint/29812
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