Citation
Mad Nasir, Nadiah and Rahmani, Mawardi and Shaari, Khozirah and Kassim, Nur Kartinee and Go, Rusea and Stanslas, Johnson and Jeyaraj, Ethel Jeyaseela
(2013)
Xanthones from Calophyllum gracilipes and their cytotoxic activity.
Sains Malaysiana, 42 (9).
pp. 1261-1266.
ISSN 0026-6039
Abstract
Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00μM.
Download File
Official URL or Download Paper: http://www.ukm.my/jsm/english_journals/vol42num9_2...
|
Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science |
| Publisher: | Universiti Kebangsaan Malaysia |
| Keywords: | Calophyllum gracilipes; Gracixanthone; Sterols; Trapezifolixanthone; Zeyloxanthanone |
| Depositing User: | Raja Norazlinda Raja Azenam |
| Date Deposited: | 08 Dec 2014 02:04 |
| Last Modified: | 07 Oct 2015 06:24 |
| URI: | http://psasir.upm.edu.my/id/eprint/29812 |
| Statistic Details: | View Download Statistic |
Actions (login required)
 |
View Item |