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Multidrug resistance protein 2 genetic polymorphism and colorectal cancer recurrence in patients receiving adjuvant FOLFOX-4 chemotherapy


Citation

Mirakhorli, Mojgan and Abdul Rahman, Sabariah and Abdullah, Syahrilnizam and Vakili, Masoud and Rozafzon, Reza and Khoshzaban, Ahad (2013) Multidrug resistance protein 2 genetic polymorphism and colorectal cancer recurrence in patients receiving adjuvant FOLFOX-4 chemotherapy. Molecular Medicine Reports, 7 (2). pp. 613-617. ISSN 1791-2997; ESSN: 1791-3004

Abstract

Multidrug resistance protein 2 (MRP2), encoded by the ATP-binding cassette C2 (ABCC2) gene, is an efflux pump located on the apical membrane of many polarized cells, which transports conjugate compounds by an ATP-dependent mechanism. The correlation of G1249A ABCC2 polymorphism with the development of colorectal cancer (CRC) and poor prognosis was evaluated in patients who were treated with fluorouracil/leucovorin (FL) plus oxaliplatin (FOLFOX-4). A total of 50 paraffin embedded tissue samples collected from CRC patients were analyzed to identify the polymorphism. Patients were in stage II/III and received postoperative FOLFOX-4 chemotherapy. As a control group, an equal number of unrelated healthy subjects were enrolled in the study. The polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and results were compared with clinicopathological markers, early relapse and survival rates. During the 12 months of follow-up, local and distant recurrences were observed in 15 (30%) patients. No significant difference in the distribution of wild-type and polymorphic genotypes was observed between the patient and control groups and between the patients who experienced recurrence within 1 year and those who did not (all P>0.05). In conclusion, the G1249A polymorphism is not associated with CRC risk and early recurrence. However, significant correlation was observed between G1249A polymorphism and the overall survival and disease-free survival of the patients.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Spandidos Publications
Keywords: ABCC2/MRP1; Colorectal cancer; G1249A; Oxaliplatin; Recurrence; Survival
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 27 Dec 2014 12:57
Last Modified: 07 Oct 2015 08:27
URI: http://psasir.upm.edu.my/id/eprint/29782
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