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Potential of 3’-fluoro-3’ deoxythymidine as a cellular proliferation marker in PET oncology examination


Citation

Hassan, Hishar and Price, Roger and Ahmad Saad, Fathinul Fikri and Lau, Eddie Wing Fai and Carpinelli, Assunta and Nordin, Abdul Jalil (2016) Potential of 3’-fluoro-3’ deoxythymidine as a cellular proliferation marker in PET oncology examination. Pertanika Journal of Science & Technology, 24 (1). pp. 41-52. ISSN 0128-7680; ESSN: 2231-8526

Abstract / Synopsis

Development of the positron emission tomography (PET) diagnostic radiopharmaceutical (18F) fluoro-2-deoxy-D-glucose (18F-FDG) subsequently facilitated the discovery and clinical evaluation of several new tracers as imaging markers for cancer. While 18F-FDG is a widely employed marker for enhanced intracellular glycolysis and metabolic function, one of the newer tracers, (18F)-3’-fluoro-3’ deoxythymidine (18F-FLT), has been developed as a biomarker for cell proliferation. In this review, the potential of 18F-FLT as a biomarker for cancer imaging is discussed.


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Additional Metadata

Item Type: Article
Divisions: Centre For Diagnostic Nuclear Imaging
Publisher: Universiti Putra Malaysia Press
Keywords: 18F-FDG; 18F-FLT; Cellular proliferation; Positron emission tomography (PET)
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 02 Aug 2016 11:02
Last Modified: 15 Nov 2017 16:12
URI: http://psasir.upm.edu.my/id/eprint/29519
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