Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release

Citation

Hussein, Ahmed S. and Ahmadun, Fakhru'l-Razi and Abdullah, Norhafizah (2013) Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release. International Journal of Polymer Analysis and Characterization, 18 (6). pp. 414-422. ISSN 1023-666X; ESSN: 1563-5341

Abstract

Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negatively charged, with good drug encapsulation efficiencies (>50%) and average particle sizes <200 nm. Interestingly, all the nanoparticles exhibited dibasic release profiles with a starting burst release within the first 8 h, followed by a controlled release phase lasting four days. Thus, linamarin-loaded nanoparticles indicate a promising candidate for controlled drug release applications.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Engineering
DOI Number:	https://doi.org/10.1080/1023666X.2013.786864
Publisher:	Taylor & Francis
Keywords:	Biodegradable; Controlled release; Linamarin; Nanoparticles; PLGA polymer
Depositing User:	Nabilah Mustapa
Date Deposited:	27 Apr 2015 07:55
Last Modified:	11 Sep 2015 02:44
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/1023666X.2013.786864
URI:	http://psasir.upm.edu.my/id/eprint/28677
Statistic Details:	View Download Statistic

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