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Cytotoxic constituents of Clausena excavata


Mohd Shariff, Nurul Waznah and Mustahil, Noorul Adawiyah and Mohd Noor, Halimatul Saadiah and Md. Sukari, Mohd Aspollah and Rahmani, Mawardi and Yap, Taufiq Yun Hin and Ee, Gwendoline Cheng Lian (2011) Cytotoxic constituents of Clausena excavata. African Journal of Biotechnology, 10 (72). art. no. 5CCFF9731856. pp. 16337-16341. ISSN 1684–5315


Phytochemical investigation on leaves, stem bark and roots of Malaysian Clausena excavata has led to the isolation and identification of limonoid compounds, clausenolide-1-methyl ether (1) and clausenarin (2), carbazole alkaloids, 3-formyl-2,7-dimethoxycarbazole (3) and clausine-K (4) together with coumarins, xanthyletin (5), dentatin (6) and nordentatin (7). Extracts of roots and isolated compounds (1), (2), (5) and (6) were subjected to cytotoxic screening against various cancer cell lines (HL-60, MCF- 7, HeLa and HT-29). All roots extracts except methanol showed strong activity against HL-60 and MCF-7 cancer cell lines with IC 50 values ranging from 4 to 6 μg/ml. Dentatin (6) was found to be the most cytotoxic constituent against all cancer cell lines with IC50 values ranging from 5 to 10 μg/ml.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.5897/AJB11.2239
Publisher: Academic Journals
Keywords: Clausena excavata; Carbazole alkaloids; Limonoids; Coumarins; Cytotoxic
Depositing User: Nur Farahin Ramli
Date Deposited: 30 Jul 2013 03:38
Last Modified: 15 Nov 2017 03:38
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5897/AJB11.2239
URI: http://psasir.upm.edu.my/id/eprint/25062
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