Citation
Mohd Shariff, Nurul Waznah and Mustahil, Noorul Adawiyah and Mohd Noor, Halimatul Saadiah and Md. Sukari, Mohd Aspollah and Rahmani, Mawardi and Yap, Taufiq Yun Hin and Ee, Gwendoline Cheng Lian
(2011)
Cytotoxic constituents of Clausena excavata.
African Journal of Biotechnology, 10 (72).
art. no. 5CCFF9731856.
pp. 16337-16341.
ISSN 1684–5315
Abstract
Phytochemical investigation on leaves, stem bark and roots of Malaysian Clausena excavata has led to the isolation and identification of limonoid compounds, clausenolide-1-methyl ether (1) and clausenarin (2), carbazole alkaloids, 3-formyl-2,7-dimethoxycarbazole (3) and clausine-K (4) together with coumarins, xanthyletin (5), dentatin (6) and nordentatin (7). Extracts of roots and isolated compounds (1), (2), (5) and (6) were subjected to cytotoxic screening against various cancer cell lines (HL-60, MCF- 7, HeLa and HT-29). All roots extracts except methanol showed strong activity against HL-60 and MCF-7 cancer cell lines with IC 50 values ranging from 4 to 6 μg/ml. Dentatin (6) was found to be the most cytotoxic constituent against all cancer cell lines with IC50 values ranging from 5 to 10 μg/ml.
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