Citation
Mohd Hashim, Najihah and Rahmani, Mawardi and Ee, Gwendoline Cheng Lian and Md.Sukari, Mohd. Aspollah and Yahayu, Maizatulakmal and Oktima, Winda and Ali, Abd Manaf and Go, Rusea
(2012)
Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus.
Journal of Biomedicine and Biotechnology, 2012 (130627).
pp. 1-9.
ISSN 1110-7243; ESSN:1110-7251
Abstract
An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC 50 values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC 50 values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC 50 values of more than 30 μg/mL.
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