New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa.

Citation

Matsuo, Hirotaka and Okamoto, Ryuichi and Zaima, Kazumasa and Hirasawa, Yusuke and Ismail, Intan Safinar and Lajis, Md. Nordin and Morita, Hiroshi (2011) New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Bioorganic & Medicinal Chemistry, 19 (13). pp. 4075-4079. ISSN 0968-0896; ESSN:1464-3391

Abstract

Villocarines A–D (1–4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations. Villocarine A (1) showed vasorelaxation activity against rat aortic ring and showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, and also inhibition effect on phenylephrine (PE)-induced contraction in the presence of nicardipine in a Ca2+ concentration-dependent manner. The vasorelaxant effect by 1 might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels (VDC) and/or receptor-operated Ca2+-channels (ROC), and also partly mediated through the increased release of NO from endothelial cells and opening of voltage-gated K+-channels.

Download File

Preview

PDF (Abstract)
New vasorelaxant indole alkaloids.pdf
Download (181kB) | Preview

Official URL or Download Paper: http://www.elsevier.com/

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.1016/j.bmc.2011.05.014
Publisher:	Elsevier
Keywords:	Villocarine A-D; Uncaria villosa; Indole alkaloids; Rubiaceae; Vasorelaxant activity.
Depositing User:	Nur Farahin Ramli
Date Deposited:	27 Aug 2013 09:26
Last Modified:	16 Oct 2015 06:58
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.bmc.2011.05.014
URI:	http://psasir.upm.edu.my/id/eprint/24848
Statistic Details:	View Download Statistic

Actions (login required)

View Item