A new abietene diterpene and other constituents from Kaempferia angustifolia Rosc.

Citation

Tang, Sook Wah and Md.Sukari, Mohd. Aspollah and Rahmani, Mawardi and Lajis, Md. Nordin and Ali, Abdul Manaf (2011) A new abietene diterpene and other constituents from Kaempferia angustifolia Rosc. Molecules, 16. pp. 3018-3028. ISSN 1431-5157; ESSN: 1420-3049

Abstract

A new abietene diterpene, kaempfolienol (5S,6S,7S,9S,10S,11R,13S-abiet-8(14)- enepenta-6,7,9,11,13-ol, 1), was isolated from a rhizome extract of Kaempferia angustifolia Rosc. along with the known compounds crotepoxide, boesenboxide, zeylenol, 2′-hydroxy-4,4′,6′-trimethoxychalcone, (24S)-24-methyl-5α-lanosta-9(11),25-dien-3β-ol, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside. The structures of all compounds were elucidated on the basis of mass spectroscopic and NMR data. Zeylenol (2), the major constituent of the plant, was derivatized into diacetate, triacetate and epoxide derivatives through standard organic reactions. The cytotoxic activity of compounds 1, 2 and the zeylenol derivatives was evaluated against the HL-60, MCF-7, HT-29 and HeLa cell lines.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.3390/molecules16043018
Publisher:	MDPI
Keywords:	Abietene diterpene; Cytotoxic; Kaempferia angustifolia; Kaempfolienol; Zeylenol.
Depositing User:	Nur Farahin Ramli
Date Deposited:	28 Feb 2014 07:21
Last Modified:	12 Jan 2016 07:11
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules16043018
URI:	http://psasir.upm.edu.my/id/eprint/24796
Statistic Details:	View Download Statistic

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