Inhibitory effects of palm a-, c- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia.

Citation

Tan, Shi Wei and Ramasamy, Rajesh and Abdullah, Maha and Vidyadaran, Sharmili (2011) Inhibitory effects of palm a-, c- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular Immunology, 271 (2011). pp. 205-209. ISSN 0008-8749; ESSN: 1090-2163

Abstract

Anti-inflammatory actions of the vitamin E fragment tocotrienol have not been described for microglia. Here, we screened palm α-, γ- and δ-tocotrienol isoforms and Tocomin® 50% (contains spectrum of tocotrienols and tocopherols) for their ability to limit nitric oxide (NO) production by BV2 microglia. Microglia were treated with varying doses of tocotrienols for 24h and stimulated with 1 μg/ml lipopolysaccharide (LPS). All tocotrienol isoforms reduced NO release by LPS-stimulated microglia, with 50 μM being the most potent tocotrienol dose. Of the isoforms tested, δ-tocotrienol lowered NO levels the most, reducing NO by approximately 50% at 48 h post-LPS treatment (p<.05). None of the tocotrienol doses tested affected microglia viability.

Download File

Preview

PDF (Abstract)
Inhibitory effects of palm a.pdf
Download (204kB) | Preview

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1016/j.cellimm.2011.07.012
Publisher:	Elsevier
Keywords:	Lipopolysaccharide; Microglia; Nitric oxide; Palm tocotrienols; Viability.
Depositing User:	Nur Farahin Ramli
Date Deposited:	18 Mar 2014 05:28
Last Modified:	12 Jan 2016 04:32
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.cellimm.2011.07.012
URI:	http://psasir.upm.edu.my/id/eprint/24566
Statistic Details:	View Download Statistic

Actions (login required)

View Item