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Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements


Citation

Chellappah Thambiah, Subashini and George, Elizabeth and Umar, Nor Aini (2011) Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements. Malaysian Journal of Medicine and Health Sciences, 7 (1). pp. 51-55. ISSN 1675-8544

Abstract

Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein. The circulating M-protein may consist of an intact immunoglobulin, the light chain only, or (rarely) the heavy chain only. The heavy chain is from one of the five immunoglobulin classes G, A, M, D or E, while the light chain is either kappa (κ) or lambda (λ) in type. Accurate detection and quantitation of monoclonal immunoglobulins is important for the diagnosis and management of monoclonal gammopathies. We report a case of a 71 year old lady with a history of chronic gastritis and recurrent lower respiratory tract infection whereby no specific diagnosis was made until a computed tomography (CT) guided lung biopsy and orogastroduodenoscopy.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Monoclonal gammopathies; Paraprotein; Amyloidosis; Light chain immunoglobulin
Depositing User: Nur Farahin Ramli
Date Deposited: 24 Mar 2014 08:24
Last Modified: 05 Jan 2018 03:07
URI: http://psasir.upm.edu.my/id/eprint/24524
Statistic Details: View Download Statistic

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