Citation
Mohd Yusoff , N. and Nuge, Tamrin and Y. Hashim, Y.Z.H. and Jamal, P. and Meor Hussin, Anis Shobirin and Abd. El Aziem, Farouk and Zainan, N.H. and Salleh, Hamzah
(2011)
Preliminary investigation of myo-inositol phosphates produced by ASUIA279 phytase on MCF-7 cancer cells.
IIUM Engineering Journal, 12 (4).
pp. 142-151.
ISSN 1511-788X
Abstract
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice brans. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 µg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 ?g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration.
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