Citation
Abstract
Purpose – The purpose of this paper is to screen cytotoxic activities of commonly used culinary plants in Malaysia, Pandanus amaryllifolius (daun pandan), Curcuma longa (turmeric leaves) and Etlingera elatior (kantan flower) against selected cancer cell lines. Design/methodology/approach – Plant samples were extracted exhaustively with ethanol and concentrated under rotary evaporator. Cytotoxic evaluation was carried out with plant extracts(0-100mg/ml) using 72-h MTT assay. Findings – Exposure of plant extracts reduced cell viability of HepG2 (hepatocellular carcinoma),HT-29 (colon carcinoma), MDA-MB-231 (non-hormone-dependent breast cancer), MCF-7(hormone-dependent breast cancer) and HeLa (cervical cancer); 50 percent inhibitory values (IC50) were obtained for MDA-MB-231, HepG2, HT-29. Extracts within the concentrations of 10-100mg/ml were found not to be effective against proliferation of MCF-7 and HeLa.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Faculty of Medicine and Health Science Faculty of Science |
| DOI Number: | https://doi.org/10.1108/00346651111151366 |
| Publisher: | Emerald Group Publishing |
| Keywords: | Curcuma longa; Cytology; Cytotoxic effect; Etlingera elatior; Malaysia; MTT assay; Pandanus amaryllifolius; Plants. |
| Depositing User: | Nur Farahin Ramli |
| Date Deposited: | 24 Feb 2014 02:30 |
| Last Modified: | 05 Oct 2015 09:19 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1108/00346651111151366 |
| URI: | http://psasir.upm.edu.my/id/eprint/24087 |
| Statistic Details: | View Download Statistic |
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