Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Jatropha curcas Linn.

Citation

Oskoueian, Ehsan and Abdullah, Norhani and Saad, Wan Zuhainis and Omar, Abdul Rahman and Ahmad, Syahida and Kuan, Wen Bin and Zolkifli, Nor Azlina and Hendra, Rudi and Ho, Yin Wan (2011) Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Jatropha curcas Linn. Journal of Medicinal Plants Research, 5 (1). pp. 49-57. ISSN 1996-0875

Abstract

A comprehensive study on the phytochemical contents and biological activities of the methanolic extract from different parts of Jatropha curcas Linn. was conducted. The extracts of different plant parts contained various levels of phenolics, flavonoids and saponins. Latex and leaf extracts showed the highest antioxidant activity. Root and latex extracts inhibited the inducible nitric oxide synthase in macrophages RAW 264.7, comparable to L-Nitro-Arginine Methyl Ester (L-NAME), indicating appreciable anti-inflammatory activities. Cytotoxicity assay results indicated the anticancer therapeutic property of the root extract against human colon adenocarcinoma (HT-29) cell line but its cytotoxic effect on human hepatocyte (Chang cell) was high.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Biotechnology and Biomolecular Sciences Institute of Bioscience
Publisher:	Academic Journals
Keywords:	Jatropha curcas Linn.; Phytochemicals; Antioxidant; Anti-inflammatory; Cytotoxicity
Depositing User:	Nurul Ainie Mokhtar
Date Deposited:	01 Sep 2015 02:25
Last Modified:	01 Sep 2015 02:25
URI:	http://psasir.upm.edu.my/id/eprint/22333
Statistic Details:	View Download Statistic

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