Secondary metabolites from two garcinia species and their biological activities.

Citation

Ee, Gwendoline Cheng Lian and Yuen, Lin Cheow (2008) Secondary metabolites from two garcinia species and their biological activities. Asian Journal of Chemistry, 20 (1). pp. 343-351. ISSN 0970-7077

Abstract

Detail chemical studies on Garcinia maingayi have yielded one xanthone, 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)xanthone, one benzophenone, isoxanthochymol, one benzoic acid derivative 3,4-dihydroxy-methylbenzoate and two triterpenoids, stigmasterol and sitosterol. Meanwhile, investigations on Garcinia parvifolia have afforded one triterpenoid, α-amyrin and two xanthones, cowanin and rubraxanthone. Their structures were derived based on spectroscopic evidence, mainly 1D and 2D NMR spectroscopy. Acetylation reaction was carried out on rubraxanthone to yield triacetate rubraxanthone. It was found that the pure rubraxanthone was strongly active against the larvae of Aedes aegypti with LC50 value of 15.49 μg/mL and HL-60 cell line with an IC50 value of 7.5 μg/mL.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
Publisher:	Chemical Publishing Co.
Keywords:	Garcinia maingayi; Garcinia parvifolia; Xanthone; Rubraxanthone.
Depositing User:	Najwani Amir Sariffudin
Date Deposited:	18 Jul 2013 01:29
Last Modified:	14 Sep 2015 08:25
URI:	http://psasir.upm.edu.my/id/eprint/16636
Statistic Details:	View Download Statistic

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