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Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation


Citation

Tan, Khang Wei and Tang, Siah Ying and Thomas, Renjan and Neela, Vasantha Kumari and Manickam, Sivakumar (2016) Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation. Pure and Applied Chemistry, 88 (1-2). pp. 43-60. ISSN 0033-4545; ESSN: 1365-3075

Abstract

Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, sterically stabilized nanoscale dispersion loaded with curcumin (nanodispersion) based on non-ionic colloidal system has been proposed. In this study, the process conditions were effectively optimized using response surface methodology (RSM) with Box–Behnken design (BBD). The suggested optimum formulation proved to be an excellent fit to the actual experimental output. STEM images illustrate that the optimal curcumin-loaded nanodispersion has spherical morphology with narrow particle size distribution. Particle size distribution study confirms that the solution pH does not affect the nanodispersion, and physical stability study shows that the colloidal system is stable over 90 days of storage at ambient conditions. More importantly, controlled release profile was achieved over 72 h and the in vitro drug release data fit well to Higuchi model (R2=0.9654).


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1515/pac-2015-0601
Publisher: Walter de Gruyter
Keywords: Anticancer activity; Antioxidants; Colloidal dispersions; Curcumin; Drug release; Green chemistry V; Nanodispersion; Nanotechnology; Optimization; Response surface methodology (RSM); Ultrasound
Depositing User: Nabilah Mustapa
Date Deposited: 08 Jun 2016 01:30
Last Modified: 08 Jun 2016 01:30
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1515/pac-2015-0601
URI: http://psasir.upm.edu.my/id/eprint/16275
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