A case of severe Plasmodium knowlesi in a splenectomized patient

Citation

Boo, Yang Liang and Lim, Hong Tak and Chin, Pek Woon and Lim, Suat Yee and Hoo, Fan Kee (2016) A case of severe Plasmodium knowlesi in a splenectomized patient. Parasitology International, 65 (1). pp. 55-57. ISSN 1383-5769; ESSN: 1873-0329

Abstract

Plasmodium knowlesi, a zoonotic malaria, is now considered the fifth species of Plasmodium causing malaria in humans. With its 24-hour erythrocytic stage of development, it has raised concern regarding its high potential in replicating and leading to severe illness. Spleen is an important site for removal of parasitized red blood cells and generating immunity. We reported a case of knowlesi malaria in a non-immune, splenectomized patient. We observed the delay in parasite clearance, high parasitic counts, and severe illness at presentation. A thorough search through literature revealed several case reports on falciparum and vivax malaria in splenectomized patients. However, literature available for knowlesi malaria in splenectomized patient is limited. Further studies need to be carried out to clarify the role of spleen in host defense against human malaria especially P. knowlesi.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1016/j.parint.2015.10.003
Publisher:	Elsevier
Keywords:	Malaria; Plasmodium knowlesi; Splenectomy
Depositing User:	Nabilah Mustapa
Date Deposited:	08 Jun 2016 01:15
Last Modified:	08 Jun 2016 01:15
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.parint.2015.10.003
URI:	http://psasir.upm.edu.my/id/eprint/16197
Statistic Details:	View Download Statistic

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