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In vitro anticoagulant activities of Melastoma malabathricum Linn. aqueous leaf extract : a preliminary novel finding.


Citation

Manicam, Caroline and Abdullah, Janna Ong and Mohd Tohit, Eusni Rahayu and Seman, Zainina and Chin, Sieo Chin and Hamid, Muhajir (2010) In vitro anticoagulant activities of Melastoma malabathricum Linn. aqueous leaf extract : a preliminary novel finding. Journal of Medicinal Plants Research, 4 (14). pp. 1464-1472. ISSN 1996-0875

Abstract

Limitations of existing anticoagulants have prompted a search for novel agents of natural origin.Fundamentals to this research was the observation that the aqueous leaf extract of Melastoma malabathricum Linn. possesses potent anticoagulant property.In vitro coagulation assays such as activated partial thromboplastin time (aPTT), prothrombin time (PT) thrombin time (TT) and mixing studies were performed on citrated plasmas of healthy volunteer donors spiked with different concentrations of the leaf exact (100-1000μg/ml).The results showed that aPTT of plasma samples spiked with extract was markedly prolonged in a concentration-dependent manner (p<0.001), but was otherwise for PT and TT. Both types of mixing studies corrected the initially prolonged aPTT to normal range.The extract exhibited no inter-gender variability in its anticoagulant activity.This study highlights that the anticoagulant activity of M. malabathricumaqueous leaf extract affects the intrinsic pathway of the coagulation cascade by causing clotting factor(s) deficiency.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.5897/JMPR10.136
Publisher: Academic Journals
Keywords: Melastoma malabathricum Linn.; Anticoagulant activity; Mixing studies.
Depositing User: Nida Hidayati Ghazali
Date Deposited: 19 Jul 2013 08:20
Last Modified: 21 Oct 2015 03:36
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5897/JMPR10.136
URI: http://psasir.upm.edu.my/id/eprint/15156
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