Citation
Abstract
Limitations of existing anticoagulants have prompted a search for novel agents of natural origin.Fundamentals to this research was the observation that the aqueous leaf extract of Melastoma malabathricum Linn. possesses potent anticoagulant property.In vitro coagulation assays such as activated partial thromboplastin time (aPTT), prothrombin time (PT) thrombin time (TT) and mixing studies were performed on citrated plasmas of healthy volunteer donors spiked with different concentrations of the leaf exact (100-1000μg/ml).The results showed that aPTT of plasma samples spiked with extract was markedly prolonged in a concentration-dependent manner (p<0.001), but was otherwise for PT and TT. Both types of mixing studies corrected the initially prolonged aPTT to normal range.The extract exhibited no inter-gender variability in its anticoagulant activity.This study highlights that the anticoagulant activity of M. malabathricumaqueous leaf extract affects the intrinsic pathway of the coagulation cascade by causing clotting factor(s) deficiency.
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Biotechnology and Biomolecular Sciences Faculty of Medicine and Health Science |
DOI Number: | https://doi.org/10.5897/JMPR10.136 |
Publisher: | Academic Journals |
Keywords: | Melastoma malabathricum Linn.; Anticoagulant activity; Mixing studies. |
Depositing User: | Ms. Nida Hidayati Ghazali |
Date Deposited: | 19 Jul 2013 08:20 |
Last Modified: | 21 Oct 2015 03:36 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5897/JMPR10.136 |
URI: | http://psasir.upm.edu.my/id/eprint/15156 |
Statistic Details: | View Download Statistic |
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