Citation
Farnia, Parissa and Masjedi, Mohammad Reza and Merza, Muayad Aghali and Tabarsi, Payam and Zhavnerko, Gennady Konstantinovich and Tengku Ibrahim, Tengku Azmi and Kuan, Ho O. and Ghanavei, Jalladein and Ranjbar, Reza and Poleschuyk, Nikolai Nikolaevich and Titov, Leonid Petrovich and Owlia, Parviz and Kazampour, Mehadi and Setareh, Mohammad and Sheikolslami, Muaryam and Migliori, Giovanni Battista and Velayati, Ali Akbar
(2010)
Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation.
International Journal of Clinical and Experimental Medicine, 3 (4).
pp. 308-314.
ISSN 1940-5901
Abstract
The ultra-structure of Mycobacterium tuberculosis (MTB) was examined by transmission electronic (TEM)) and atomic force microscopy (AFM). The study was performed to describe the morphology of susceptible, multidrug-resistant (MDR), extensively drug-resistant (XDR) and extremely drug-resistant tuberculosis isolates (XXDR-TB) during their exponential growth phase. Four types of cell division were observed and described. While three of them (symmetrical, asymmetrical and branching type) occurred in all isolates studied, the fourth one (adapted type) was seen only in XDR and XXDR-TB bacilli. In the fourth type of cell division, a rod shaped mother cell produced a small round shape bacillus (0.3-0.5 μm). These round cells were different from buds or polar division, but similar to terminal endospores without showing the typing heat resistance. Based on the present observation, we suggest that XDR-and XXDR-TB bacilli accommodate changes helping them to overcome the hostile environment. Viewed under AFM, the other frequently detected shapes in MTB isolates were oval, V, Y and multi-branching filaments. These shape variation confirmed pleomorphic phenomena in MTB populations and the specific features of pan-resistant strains
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