Genotoxic effect of Catha edulis (khat) crude extract after sub-chronic administration in rats.

Citation

Al-Zubairi, Adel Sharaf and Ismail, Patimah and Chong, Pei Pei and Rahmat, Asmah (2008) Genotoxic effect of Catha edulis (khat) crude extract after sub-chronic administration in rats. Environmental Toxicology and Pharmacology, 25 (3). pp. 298-303. ISSN 1382-6689; ESSN 1872-7077

Abstract

The aim of this study was to evaluate the genotoxic effects of a crude extract of khat (Catha edulis, Forsk) leaves in rats. Two groups were fed khat crude extract, 1000 and 2000 mg/kg body weight, for 90 days and were compared with a control group. The alkaline (pH > 13) version of comet assay was used in this study. However, no previous published work has been undertaken and showed the effect of khat on DNA migration in the comet assay. To compare the comet assay results with another genetic endpoint, blood samples were analyzed for chromosomal aberrations. These results showed no DNA damage detected using comet assay in both the khat treated groups, while the results of chromosomal aberrations assay showed a significant increase (P < 0.05) in the 2000 mg/kg body weight treated group compared to the control group.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1016/j.etap.2007.10.032
Publisher:	Elsevier
Keywords:	Catha edulis; Chromosome aberration assay; Comet assay; Genotoxicity; Khat.
Depositing User:	Raja Norazlinda Raja Azenam
Date Deposited:	18 Oct 2013 01:56
Last Modified:	02 Dec 2015 02:19
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.etap.2007.10.032
URI:	http://psasir.upm.edu.my/id/eprint/14885
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