Citation
Baharuldin, Mohamad Taufik Hidayat and Apryani, Evhy and Mohamad, Nabishah and Mohd Moklas, Mohamad Aris and Fakurazi, Sharida and Adzhar, Muhammad Farhan
(2010)
Determination of mitragynine bound opioid receptors.
Advances in Medical and Dental Sciences, 3 (3).
pp. 65-70.
ISSN 1995-0764; ESSN: 1998-1082
Abstract
Mitragyna Speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-like stimulant ability to combat fatigue and enhance tolerance to hard work. This study is designed to examine the binding affinity and selectivity of mitragynine towards opioid receptors namely µ-, δ-, and κ-receptors and the density of those opioid receptors in brain tissues, spinal cord, duodenum, ileum and vas deferens. Our results suggest that mitragynine has a high affinity to the 9-opioid receptors and brain has the highest density of opioid receptors.
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Official URL or Download Paper: http://arnmsmb.com/old/amds_sept-dec_2009.html
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science |
| Publisher: | American-Eurasian Network for Scientific Information |
| Keywords: | Mitragyna speciosa; Mitragynine; Opioid; Receptors; Binding affinity |
| Depositing User: | Raja Norazlinda Raja Azenam |
| Date Deposited: | 30 Apr 2014 08:46 |
| Last Modified: | 08 Nov 2017 03:06 |
| URI: | http://psasir.upm.edu.my/id/eprint/13954 |
| Statistic Details: | View Download Statistic |
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