Citation
Abstract
This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260–300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (−11.4% to −18.5%), LDL-C (−22% to −49.3%), and TG (−33.7% to −36.1%) levels and significantly increased HDL-C levels (16.3–55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats.
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Official URL or Download Paper: http://online.liebertpub.com/doi/abs/10.1089/jmf.2...
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Food Science and Technology Faculty of Veterinary Medicine |
DOI Number: | https://doi.org/10.1089/jmf.2008.1212 |
Publisher: | Mary Ann Liebert |
Keywords: | Cardiovascular; Seaweeds; Rats; Hypercholesterol; Hyperlipidemia |
Depositing User: | Khairil Ridzuan Khahirullah |
Date Deposited: | 06 Nov 2013 04:07 |
Last Modified: | 18 Apr 2016 08:33 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1089/jmf.2008.1212 |
URI: | http://psasir.upm.edu.my/id/eprint/13684 |
Statistic Details: | View Download Statistic |
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