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C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population.


Citation

Vasudevan, Ramachandran and Ismail, Patimah and Stanslas, Johnson and Shamsudin, Norashikin (2008) C-511T polymorphism of interleukin-1 β gene is not associated in type 2 diabetes mellitus - a study in Malaysian population. Journal of Medical Sciences, 8 (3). pp. 216-221. ISSN 1682-4474; ESSN : 1812-5727

Abstract

The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Gerontology
DOI Number: https://doi.org/10.3923/jms.2008.216.221
Publisher: Asian Network for Scientific Information
Keywords: Cytokines; Interleukin -1 β gene; PCR-RFLP; Polymorphism; Type 2 diabetes mellitus
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 13 Nov 2014 07:08
Last Modified: 08 Oct 2015 02:31
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/jms.2008.216.221
URI: http://psasir.upm.edu.my/id/eprint/13469
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