Citation
Abstract
The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population.
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Official URL or Download Paper: http://scialert.net/abstract/?doi=jms.2008.216.221
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Institute of Gerontology |
| DOI Number: | https://doi.org/10.3923/jms.2008.216.221 |
| Publisher: | Asian Network for Scientific Information |
| Keywords: | Cytokines; Interleukin -1 β gene; PCR-RFLP; Polymorphism; Type 2 diabetes mellitus |
| Depositing User: | Raja Norazlinda Raja Azenam |
| Date Deposited: | 13 Nov 2014 07:08 |
| Last Modified: | 08 Oct 2015 02:31 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/jms.2008.216.221 |
| URI: | http://psasir.upm.edu.my/id/eprint/13469 |
| Statistic Details: | View Download Statistic |
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