Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus

Citation

Ee, Gwendoline Cheng Lian and Siow, Hwa Teo and Rahmani, Mawardi and Lim, Chan Kiang and Lim, Yang Mooi and Bong, Joseph Choon Fah (2010) Artosimmin: potential anti-cancer lead compound from Artocarpus odoratissimus. Letters in Organic Chemistry, 7 (3). pp. 240-244. ISSN 1570-1786; ESSN: 1875-6255

Abstract

Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.2174/157017810791112379
Publisher:	Bentham Science Publishers Ltd.
Keywords:	Artocarpus odoratissimus; Moraceae; Pyranoflavone; Triterpenoid; Cytotoxicity; Antioxidant
Depositing User:	Nurul Ainie Mokhtar
Date Deposited:	08 Jun 2015 02:11
Last Modified:	10 Sep 2015 04:05
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/157017810791112379
URI:	http://psasir.upm.edu.my/id/eprint/13279
Statistic Details:	View Download Statistic

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