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Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats


Citation

Abbasalipourkabirreh, Roghayeh and Salehzadeh, Aref and Abdullah, Rasedee (2010) Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats. African Journal of Biotechnology, 9 (43). art. no. 31BD94F26064. pp. 7337-7345. ISSN 1684–5315

Abstract

An in vivo study was conducted to determine the effect of tamoxifen-loaded solid lipid nanoparticle on LA7 cell-induced rat mammary tumor. After the first tumors appearance, the thirty rats were divided into five groups. Group I served as normal control animal. The other four groups were mammary gland tumor-bearing animals treated with soy oil (Group II), tamoxifen (TAM) dissolved in soy oil (Group III), tamoxifen-loaded solid lipid nanoparticle (Group IV) and solid lipid nanoparticle (SLN) (Group V) dispersed in soy oil. The effect of TAM-loaded SLN in the reduction of tumor size was greater than that of free TAM. The transmission electron microscope analysis showed apoptosis in TAM-loaded SLN and free TAM treatment groups. After treatment, the rats treated with TAM-loaded SLN showed decreases in concentration of serum enzymes. In conclusion, the study suggests that TAM-loaded SLN is very effective for treatment of rat mammary gland tumors and breast cancers.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Academic Journals
Keywords: Mammary tumor gland; Sprague-Dawley rat; Tamoxifen loaded solid lipid nanoparticle
Depositing User: Azizan Arshad
Date Deposited: 09 Dec 2013 07:25
Last Modified: 30 Jun 2016 02:22
URI: http://psasir.upm.edu.my/id/eprint/13209
Statistic Details: View Download Statistic

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